TSimaging Healthcare is founded in 2016 by Tsinghua University and  world-renowned scientists and experts in the industry. The company aims to transform the scientific research results of the Tsinghua University Biomedical Imaging Research Center, adhering to the advanced medical solutions to serve doctors and  aid patients with precise imaging based on the concept of diagnostic methods, a series of advanced imaging solutions.

TSimaging Healthcar

Performance of multi-contrast MRI plaque imaging has been validated by histology.

​Saam T, et al. ATVB. 2005

Cardiovascular and cerebrovascular diseases have been the No.1 killer in the world for decades according to the report from The World Health Organization. It is now an urgent issue on how to effectively treat stroke victims worldwide. Atherosclerotic plaques are closely related to ischemic stroke. Rupture of vulnerable plaques causing thrombosis can lead to ischemia and necrosis of brain.

In order to prevent and control a stroke, it is important to identify and treat plaques at an early stage.

In a conventional diagnosis of carotid plaques, ultrasound, CT or DSA were used to measure the severity of stenosis. However, many studies have shown that the degree of stenosis frequently underestimates plaque severity, causing patients to miss the best treatment opportunity. Plaque vulnerability associated with plaque components, which has been supported by histology, would be a strong predictor for an ischemic stroke.

The best solution of evaluating plaque vulnerability would be high-resolution MR vessel wall imaging. We have developed this technology to delineate the vessel wall structure and visualize plaque components more clearly.

Beijing TSImaging Healthcare Technology Co., Ltd

Address：Room 503, Building 2, Medical Center, Zhongguancun Life                             Science Park, Changping District, Beijing, China  

Tel：+8618610816986

E-mail：market@tsimaging.net

Vulnerable plaque: characteristics in multi-contrast MRI.

​Cai JM, et al. Circulation.2002

Multi-contrast joint intra and extra-cranial 

MR sequences

      Well-trained specialists, image interpretation software, precise and accurate reports, within 24 hours

Custom-designed 8 channel carotid coil

PLAQUECARE solution, developed by TSimaging Healthcare collaborated with CBIR, contains the following products:

      • Custom-designed vascular coils

      • Standardized black-blood vessel wall MR imaging protocols

      • Plaque image processing workstation

PLAQUECARE meets the VesselAID^TM standard and ensures its application by providing professional training for our customers.​

Multi-contrast carotid plaque MR sequences

      Multi-contrast carotid plaque MR sequences provide TOF, Hyper T1-w, T1-w and T2-w images to qualitatively and quantitatively assess carotid morphology and plaque components.

      In addition, we also have developed 3D large-coverage multi-contrast MR sequences, covering a field of view from common carotid arteries to internal carotid arteries and vertebral arteries.

3D variable flip angle turbo spin echo sequence

• 3D isotropic resolution imaging
• Allow multi-planar reconstruction
• Large coverage: assessment of wall morphology and plaque distribution

​Zhou Z, et al. JCMR. 2015

SNAP (Simultaneous non-contrast MR angiography and IPH imaging)

• Hyper T1-w, sensitive to IPH
• 3D isotropic resolution imaging
• Allow multi-planar reconstruction
• Large coverage: assessment of wall morphology and plaque distribution

​Wang J, et al. MRM. 2013

Standardized carotid plaque scan workflow

PLAQUECARE carotid solution: 

what we have

Imaging Coils

• Multi-channel
• Ultra-high SNR
• Large coverage
• Compatible with parallel imaging
• Easy to use

Imaging techniques​

• Multi-contrast and high resolution

• Effective blood suppression
• Co-registered multi-contrast sequences
• Simplified scan procedure
• ECG/PPU gating free
• Faster
• Clear images, easy to interpret
• Precise imaging of plaque

User Training​

• Standardized data manipulation

• High image quality for interpretation
• Research collaboration with CBIR

Imaging Coils

• Multi-channel phase array coil
• Ultra-high SNR
• One-stop joint intra- and extra-cranial imaging
• Compatible with fast imaging
• Lightweight

Imaging techniques​

• Multi-contrast black-blood MR sequences
• Isotropic high resolution acquisition
• multi planar reconstruction
• Simplified scan procedure
• ECG/PPU gating free

User Training​

• Standardized data manipulation
• High image quality for interpretation
• Research collaboration with CBIR

One-stop intra and extra-cranial plaque

 scan workflow

Coronal view

Axial view

• Degree of stenosis

• Area (lumen/wall/vessel)
• Volume(lumen/wall/vessel)
• Wall thickness(Maximum/minimum/mean)

Quantitative measurements

Plaque  image processing workstation 

High performance workstation

• High performance hardware and system, support big data processing.
• ​High-resolution monitor, display in details.

Specific workflow for different vascular beds

Precise analysis of  3D MR plaque images

Qualitative analysis​

• Image quality assessment

• Lumen surface conditions
• Plaque stability
• AHA types
• Plaque risk score

Vessel morphology

Plaque components

• Lipid-rich necrotic core (Volume & proportion)
• Intra-plaque hemorrhage (Volume & proportion)
• Calcification (Volume & proportion)
• Fibrous cap thickness
• Thrombus volume

• Dignal intensity analysis（optional）
• Dynamic contrast enhancement analysis（optional）

Senior interpretation team

Experienced experts from both China and the U.S to provide reliable diagnosis.

Diagnostic report

user-defined output, built-in templates

CASE II

Male, 58 years old, sudden numbness and weakness in left limb, headaches for 6 hours.

Diabetes for 10 years, hypertension for 10 years.

DSA: 

Right ICA occlusion; atherosclerosis in left intracranial and carotid arteries.

MRI:

acute cerebral infarction in right corona radiate.right internal carotid artery: invisible;vulnerable plaque (red arrows) and thrombus (red triangles) in right ICA.

Comment: MR plaque imaging is the best way to diagnose the ischemic stroke by precisely identifying vulnerable plaques in intra-and extra-cranial arteries.

Comment: Plaque composition, rather than stenosis, is the best indicator of plaque vulnerability. MR vessel wall imaging is the first choice to evaluate vulnerable plaque by directly revealing the pathological characteristics of plaque.

CASE V

CASE VI

CASE IV

Female, 31 years old, intermittent insomnia for 4 years and gradually aggravate more than 20 days with headaches.

MRI:

One-stop carotid artery wall imaging clearly and comprehensively shows the large-scale annular thickening of the left and right common carotid arteries, with the left side as the weight, resulting in obvious stenosis of the lumen, which is consistent with changes in arterial vasculitis.

Male, 50 years old, weakness in right limb for 3 days

MRI: 

Acute cerebral infarction in left corona radiate; no stenosis in bilateral ICA; occlusion in M1 segment of left MCA. MR plaque imaging shows atherosclerotic plaque formation in M1 segment of left MCA.

Comment: MR plaque imaging can not only visualize extra-cranial, but also intra-cranial atherosclerotic plaques.

Male, 73 years old, intermittent dizzy for one year，syncope occurs twice.

MRI: 

vulnerable plaque in right carotid artery; clinical symptoms disappear after CEA.

Figure A: no cerebrovascular stenosis on TOF-MRA

Figure B: Plaque in left carotid artery

Figure C: Plaque in right carotid artery (before CEA)

Figure D: Plaque in right carotid artery (after CEA)​

Male, 79 years old, sudden numbness in left limb, dyskinesia, dizziness for 8 days

MRI:

IPH (red arrows) in right ICA and mixed plaque (red triangles) in left carotid artery;

Acute cerebral infarction in right basal ganglia in DWI and T2-FLAIR.By combining this information, we can confirm that plaque with IPH in right ICA is the culprit plaque.

Male, 56 years old, sudden numbness in right limb, aphasia for 4 days, TIA for 2-3 years

MRI: 

Dissection in left ICA, including true and false lumen, intimal flap and inflammatory infiltration, can be clearly visualized in curved multi-planar reconstruction images.